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Article

Relationship between γ-interferon gene polymorphisms and susceptibility to brucellosis infection.

Microbiology and immunology - 1 Nov 2013

Eskandari-Nasab Ebrahim, Moghadampour Mehdi, Hasani Seyed-Shahaboddin, Hadadi-fishani Mehdi, Mirghanizadeh-Bafghi Seyyed-Ali, Asadi-Saghandi Abolghasem, Zare Fateme, Sadeghi-Kalani Behrooz, Ghazali-bina Mehran

Abstract excerpt

Interferon-gamma (IFN-γ) is a pro-inflammatory cytokine that plays a pivotal role in the defense mechanism against Brucella infection. It was hypothesized that the IFN-γ in (+874 A/T in intron 1) TT and +5644 T/A, TT genotypes, which are reportedly associated with high IFN production, are associated with susceptibility to brucellosis in Iranian subjects. Genotyping of these IFN-γ variants by an allele-specific...

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PMID: 24033468
DOI: 10.1111/1348-0421.12093

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Source receipt: pubmed, retrieved 7 Sept 2026.

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