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Article

The Goat Cytotoxic T Lymphocyte-Associated Antigen-4 Gene: mRNA Expression and Association Analysis of Insertion/Deletion Variants with the Risk of Brucellosis.

International journal of molecular sciences - 11 Oct 2024

Wang Congliang, Liu Xiaoyu, Ren Zhaofei, Du Xiaomin, Li Na, Song Xiaoyue, Wu Weiwei, Qu Lei, Zhu Haijing, Hua Jinlian

Abstract excerpt

The cytotoxic T lymphocyte-associated antigen-4 (CTLA4) gene, a member of the immunoglobulin superfamily, is crucial for maintaining immune homeostasis and preventing autoimmune diseases. Studies have shown that polymorphisms in the CTLA4 gene are linked to an increased risk of brucellosis in humans, but its association with brucellosis in goats remains unexplored. In this study, the tissue expression profile of...

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PMID: 39456732
DOI: 10.3390/ijms252010948
PMCID: PMC11506940

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