Article
Polymorphisms of human placental alkaline phosphatase are associated with in vitro fertilization success and recurrent pregnancy loss.
The American journal of pathology - 1 Feb 2014
Vatin Magalie, Bouvier Sylvie, Bellazi Linda, Montagutelli Xavier, Laissue Paul, Ziyyat Ahmed, Serres Catherine, De Mazancourt Philippe, Dieudonné Marie-Noelle, Mornet Etienne, Vaiman Daniel, Gris Jean-Christophe
Abstract excerpt
Fertility is a quantitative, complex character governed by a considerable number of genes. Despite clinical and scientific advances, several cases of human infertility remain unexplained. In the present study, using a positional cloning approach in a mouse model of interspecific recombinant lines, a candidate gene, ALPP, encoding the placental alkaline phosphatase, was identified as being potentially involved in...
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