Article
A sequence variation in the promoter of the placental alkaline phosphatase gene (ALPP) is associated with allele-specific expression in human term placenta.
Placenta - 1 Sept 2010
Bellazi L, Germond S, Dupont C, Brun-Heath I, Taillandier A, De Mazancourt P, Dieudonné M N, Mornet E
Abstract excerpt
Placental alkaline phosphatase (PLAP), encoded by the ALPP gene, is produced by the fetal side of the placenta. This enzyme displays strong genetic variability. Some of the variants were reported to be associated with pathology of pregnancy. We show here that the two most common ALPP allelic variants, Pl(1) and Pl(2), differ in mRNA expression level. This differential expression was independent of the parental...
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