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Article

Differential contribution of basic residues to HIV-1 nucleocapsid protein's nucleic acid chaperone function and retroviral replication.

Nucleic acids research - 1 Feb 2014

Wu Hao, Mitra Mithun, Naufer M Nabuan, McCauley Micah J, Gorelick Robert J, Rouzina Ioulia, Musier-Forsyth Karin, Williams Mark C

Abstract excerpt

The human immunodeficiency virus type 1 (HIV-1) nucleocapsid (NC) protein contains 15 basic residues located throughout its 55-amino acid sequence, as well as one aromatic residue in each of its two CCHC-type zinc finger motifs. NC facilitates nucleic acid (NA) rearrangements via its chaperone activity, but the structural basis for this activity and its consequences in vivo are not completely understood. Here, we...

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Identifiers

PMID: 24293648
DOI: 10.1093/nar/gkt1227
PMCID: PMC3936775

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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