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Article

C-terminal domain modulates the nucleic acid chaperone activity of human T-cell leukemia virus type 1 nucleocapsid protein via an electrostatic mechanism.

The Journal of biological chemistry - 1 Jan 2010

Qualley Dominic F, Stewart-Maynard Kristen M, Wang Fei, Mitra Mithun, Gorelick Robert J, Rouzina Ioulia, Williams Mark C, Musier-Forsyth Karin

Abstract excerpt

Retroviral nucleocapsid (NC) proteins are molecular chaperones that facilitate nucleic acid (NA) remodeling events critical in viral replication processes such as reverse transcription. Surprisingly, the NC protein from human T-cell leukemia virus type 1 (HTLV-1) is an extremely poor NA chaperone. Using bulk and single molecule methods, we find that removal of the anionic C-terminal domain (CTD) of HTLV-1 NC...

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Identifiers

PMID: 19887455
DOI: 10.1074/jbc.M109.051334
PMCID: PMC2804176

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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