Article
A tripeptide (NSK) inhibits Japanese encephalitis virus infection in vitro and in vivo.
Archives of virology - 1 May 2014
Li Chen, Ge Ling-ling, Yu Ya-ling, Huang Li, Wang Yue, Sun Ming-xia, Ishag Hassan, Ma Liang-xiao, Li Xue-hua, Shen Zhi-qiang, Mao Xiang
Abstract excerpt
Japanese encephalitis virus (JEV) is a major pathogen that can cause acute viral encephalitis in both humans and animals. Domain III of the viral envelope protein (EDIII) is involved in binding to host cell receptor(s) to facilitate virus entry. Our previous study showed that the loop3 peptide of EDIII possesses antiviral activity against JEV infection. In this paper, we demonstrate that three residues (NSK) in...
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