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Article

A Single siRNA Suppresses Fatal Encephalitis Induced by Two Different Flaviviruses

7 Feb 2006

Abstract excerpt

BACKGROUND: Japanese encephalitis virus (JEV) and West Nile virus (WNV) are neurotropic flaviviruses that can cause acute encephalitis with a high fatality rate. Currently there is no effective treatment for these infections. METHODS AND FINDINGS: We tested RNA interference (RNAi)-based intervention to suppress lethal JE and WN encephalitis in mice. To induce RNAi, we used either lentivirally expressed short...

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PMID: 16464133
DOI: 10.1371/journal.pmed.0030096

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