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Article

[Molecular pathogenesis of ALS in TDP43 era].

Rinsho shinkeigaku = Clinical neurology - 1 Jan 2013

Onodera Osamu

Abstract excerpt

To clarify the molecular pathogenesis of amyotrophic lateral sclerosis (ALS) associated with TAR-DNA binding protein 43 kDd (TDP-43), the quality and quantity of TDP-43 take a crucial role. Regarding to the quality of TDP-43, TDP-43 has been reported as an aggregate-prone protein. Especially the C-terminus of the TDP-43 tends to form aggregate and has prion-like domain. Interestingly the mutations in the genes,...

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Source

Identifiers

PMID: 24291884
DOI: 10.5692/clinicalneurol.53.1077

Genes

GEM

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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