Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum.

Neurology - 6 Oct 2009

Goizet C, Boukhris A, Maltete D, Guyant-Maréchal L, Truchetto J, Mundwiller E, Hanein S, Jonveaux P, Roelens F, Loureiro J, Godet E, Forlani S, Melki J, Auer-Grumbach M, Fernandez J C, Martin-Hardy P, Sibon I, Sole G, Orignac I, Mhiri C, Coutinho P, Durr A, Brice A, Stevanin G

Abstract excerpt

OBJECTIVE: Hereditary spastic paraplegias (HSPs) are very heterogeneous inherited neurodegenerative disorders. Our group recently identified ZFYVE26 as the gene responsible for one of the clinical and genetic entities, SPG15. Our aim was to describe its clinical and mutational spectra. METHODS: We analyzed all exons of SPG15/ZFYVE26 gene by direct sequencing in a series of 60 non-SPG11 HSP subjects with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Carrier Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Corpus Callosum

Share to Magnetic Resonance Imaging

Share to Positron-Emission Tomography

Share to Severity of Illness Index

Share to Spastic Paraplegia, Hereditary

Share to Tomography, Emission-Computed, Single-Photon

Source

Identifiers

PMID: 19805727
DOI: 10.1212/WNL.0b013e3181bacf59

Genes

ZFYVE26
SPG11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

SPG15 is the second most common cause of hereditary spastic paraplegia with thin corpus callosum.PMID 19805727Read ↗

The clinical and molecular spectrum of ZFYVE26-associated hereditary spastic paraplegia: SPG15.Semantic proximity Read ↗

Investigating ZFYVE26 mutations in a Taiwanese cohort with hereditary spastic paraplegia.Semantic proximity Read ↗

Overlapping phenotypes in complex spastic paraplegias SPG11, SPG15, SPG35 and SPG48.Semantic proximity Read ↗

Further clinical and genetic characterization of SPG11: hereditary spastic paraplegia with thin corpus callosum.Semantic proximity Read ↗

Identification of the SPG15 gene, encoding spastizin, as a frequent cause of complicated autosomal-recessive spastic paraplegia, including Kjellin syndrome.Semantic proximity Read ↗

Review of the Genetic Spectrum of Hereditary Spastic Paraplegias in the Middle East and North Africa RegionsSemantic proximity Read ↗

SPG11 mutations are common in familial cases of complicated hereditary spastic paraplegia.Semantic proximity Read ↗

Mutations in SPG11, encoding spatacsin, are a major cause of spastic paraplegia with thin corpus callosum.Semantic proximity Read ↗

Frequency and phenotype of SPG11 and SPG15 in complicated hereditary spastic paraplegia.Semantic proximity Read ↗

Clinical Progression and Genetic Analysis in Hereditary Spastic Paraplegia With Thin Corpus Callosum in Spastic Gait Gene 11 (SPG11)Semantic proximity Read ↗

A novel locus for hereditary spastic paraplegia with thin corpus callosum and epilepsy.Semantic proximity Read ↗

SPG11 compound mutations in spastic paraparesis with thin corpus callosum.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.