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Article

Ligands for glaucoma-associated myocilin discovered by a generic binding assay.

ACS chemical biology - 21 Feb 2014

Orwig Susan D, Chi Pamela V, Du Yuhong, Hill Shannon E, Cavitt Marchello A, Suntharalingam Amrithaa, Turnage Katherine C, Dickey Chad A, France Stefan, Fu Haian, Lieberman Raquel L

Abstract excerpt

Mutations in the olfactomedin domain of myocilin (myoc-OLF) are the strongest link to inherited primary open angle glaucoma. In this recently identified protein misfolding disorder, aggregation-prone disease variants of myocilin hasten glaucoma-associated elevation of intraocular pressure, leading to vision loss. Despite its well-documented pathogenic role, myocilin remains a domain of unknown structure or...

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Identifiers

PMID: 24279319
DOI: 10.1021/cb4007776
PMCID: PMC3944078

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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