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Article

Discovering subgroups of patients from DNA copy number data using NMF on compacted matrices.

PloS one - 1 Jan 2013

de Campos Cassio P, Rancoita Paola M V, Kwee Ivo, Zucca Emanuele, Zaffalon Marco, Bertoni Francesco

Abstract excerpt

In the study of complex genetic diseases, the identification of subgroups of patients sharing similar genetic characteristics represents a challenging task, for example, to improve treatment decision. One type of genetic lesion, frequently investigated in such disorders, is the change of the DNA copy number (CN) at specific genomic traits. Non-negative Matrix Factorization (NMF) is a standard technique to reduce...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24278162
DOI: 10.1371/journal.pone.0079720
PMCID: PMC3835832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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