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Article

Constructing endophenotypes of complex diseases using non-negative matrix factorization and adjusted rand index.

PloS one - 1 Jan 2012

Wang Hui-Min, Hsiao Ching-Lin, Hsieh Ai-Ru, Lin Ying-Chao, Fann Cathy S J

Abstract excerpt

Complex diseases are typically caused by combinations of molecular disturbances that vary widely among different patients. Endophenotypes, a combination of genetic factors associated with a disease, offer a simplified approach to dissect complex trait by reducing genetic heterogeneity. Because molecular dissimilarities often exist between patients with indistinguishable disease symptoms, these unique molecular...

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Identifiers

PMID: 22815890
DOI: 10.1371/journal.pone.0040996
PMCID: PMC3397992

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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