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Article

In vivo mRNA expression of a multi-mechanistic mAb combination protects against Staphylococcus aureus infection

31 May 2024

Abstract excerpt

Single monoclonal antibodies (mAbs) can be expressed in vivo through gene delivery of their mRNA formulated with lipid nanoparticles (LNPs). However, delivery of a mAb combination could be challenging due to the risk of heavy and light variable chain mispairing. We evaluated the pharmacokinetics of a three mAb combination against Staphylococcus aureus first in single chain variable fragment scFv-Fc and then in...

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PMID: 38822525
DOI: 10.1016/j.ymthe.2024.05.036

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