Article
Diagnostic utility of BRAFV600E mutation testing in thyroid nodules in elderly patients.
BMC surgery - 1 Jan 2013
Guerra Anna, Di Crescenzo Vincenzo, Garzi Alfredo, Cinelli Mariapia, Carlomagno Chiara, Pepe Stefano, Zeppa Pio, Tonacchera Massimo, Vitale Mario
Abstract excerpt
BACKGROUND: Thyroid cancer is a rare disease characterized by the subtle appearance of a nodule. Fine-needle cytology (FNC) is the first diagnostic procedure used to distinguish a benign from a malignant nodule. However, FNC yields inconclusive results in about 20% of cases. BRAF(V600E) mutation is the most frequent genetic alteration in papillary thyroid carcinoma (PTC); its high prevalence makes this oncogene a...
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