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Methionine synthase reductase A66G polymorphism and leukemia risk: evidence from published studies.

Leukemia & lymphoma - 1 Aug 2014

Fang Dai-Hua, Ji Qiang, Fan Cong-Hai, An Qi, Li Juan

Abstract excerpt

Methionine synthase reductase (MTRR) is required for the reductive methylation of cobalamin, which is the functional cofactorial form of methionine synthase (MS) in the remethylation of homocysteine to methionine. The MTRR A66G (rs1801394) polymorphism is found to be associated with decreased enzyme affinity for MTR, the gene that encodes MS, and has been widely investigated for cancer risk, including leukemia....

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Identifiers

PMID: 24261678
DOI: 10.3109/10428194.2013.867492

Genes

MTRR
MTR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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