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Article

Gene-level integrated metric of negative selection (GIMS) prioritizes candidate genes for nephrotic syndrome.

PloS one - 1 Jan 2013

Sampson Matthew G, Gillies Christopher E, Ju Wenjun, Kretzler Matthias, Kang Hyun Min

Abstract excerpt

Nephrotic syndrome (NS) gene discovery efforts are now occurring in small kindreds and cohorts of sporadic cases. Power to identify causal variants in these groups beyond a statistical significance threshold is challenging due to small sample size and/or lack of family information. There is a nee...

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Share to Databases, Genetic
Share to Genes, Recessive
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glomerulosclerosis, Focal Segmental

Share to Kidney Glomerulus

Share to Nephrotic Syndrome

Share to Podocytes

Share to Selection, Genetic

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Identifiers

PMID: 24260533
DOI: 10.1371/journal.pone.0081062
PMCID: PMC3832435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24260533-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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