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Article

Epigenetic deregulation of the LMP1/LMP2 locus of Epstein-Barr virus by mutation of a single CTCF-cohesin binding site.

Journal of virology - 1 Feb 2014

Chen Horng-Shen, Martin Kayla A, Lu Fang, Lupey Lena N, Mueller Joshua M, Lieberman Paul M, Tempera Italo

Abstract excerpt

The chromatin regulatory factors CTCF and cohesin have been implicated in the coordinated control of multiple gene loci in Epstein-Barr virus (EBV) latency. We have found that CTCF and cohesin are highly enriched at the convergent and partially overlapping transcripts for the LMP1 and LMP2A genes, but it is not yet known how CTCF and cohesin may coordinately regulate these transcripts. We now show that genetic...

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Share to CCCTC-Binding Factor
Share to Chromosomal Proteins, Non-Histone

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Epstein-Barr Virus Infections

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Share to Herpesvirus 4, Human

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Source

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Identifiers

PMID: 24257606
DOI: 10.1128/JVI.02209-13
PMCID: PMC3911611

Genes

CTCF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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