Use of PKA-mediated phenotypes for genetic and small-molecule screens in Schizosaccharomyces pombe.

doi:10.1042/BST20130159

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Article

Use of PKA-mediated phenotypes for genetic and small-molecule screens in Schizosaccharomyces pombe.

Biochemical Society transactions - 1 Dec 2013

de Medeiros Ana Santos, Magee Alexander, Nelson Kyle, Friedberg Liora, Trocka Karolina, Hoffman Charles S

Abstract excerpt

PKA (protein kinase A) in the fission yeast Schizosaccharomyces pombe controls transcription of genes involved in metabolism, cell growth and sexual development. In the present review, we discuss phenotypes associated with either high or low PKA activity in the context of how they can be used to carry out genetic or small-molecule screens that affect components of the PKA pathway. Although our recent research has...

Topics

Cyclic AMP-Dependent Protein Kinases
Phenotype
Schizosaccharomyces
Schizosaccharomyces pombe Proteins

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Open in PubMed

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PMID: 24256276
DOI: 10.1042/BST20130159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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