Aberrant immunoarchitecture distinguishes hyperplastic germinal centres in pattern 1 angioimmunoblastic T-cell lymphoma from reactive follicles.

doi:10.1002/hon.2116

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Article

Aberrant immunoarchitecture distinguishes hyperplastic germinal centres in pattern 1 angioimmunoblastic T-cell lymphoma from reactive follicles.

Hematological oncology - 1 Sept 2014

Tan Leonard Hwan-Cheong, Tan Soo-Yong

Abstract excerpt

We compare 30 biopsies each of Pattern 1 angioimmunoblastic T-cell lymphoma (AITL1) and reactive lymphoid hyperplasia (RLH) by immunohistology, in-situ hybridization for Epstein-Barr virus-encoded RNA and T-cell receptor-γ (TRG)-clonality. AITL1 cases, more often than RLH controls, were older [median ages 61 (range 23-79) vs 46 (range 11-59) years, p < 10(-4)], non-Chinese [16/30 (53%) vs 8/28 (29%), p = 0.035],...

Topics

Adult
Aged
Antigens, Surface
Biomarkers
Female
Germinal Center
Humans
Immunoblastic Lymphadenopathy
Immunohistochemistry
Lymphoid Tissue
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Phenotype

Pseudolymphoma

Reproducibility of Results

Sensitivity and Specificity

Young Adult

Source

Open in PubMed

Identifiers

PMID: 24254640
DOI: 10.1002/hon.2116

Genes

TRG
ICOS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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