Article
Colorectal cancer risk variants on 11q23 and 15q13 are associated with unexplained adenomatous polyposis.
Journal of medical genetics - 1 Jan 2014
Hes Frederik J, Ruano Dina, Nieuwenhuis Marry, Tops Carli M, Schrumpf Melanie, Nielsen Maartje, Huijts Petra E A, Wijnen Juul T, Wagner Anja, Gómez García Encarna B, Sijmons Rolf H, Menko Fred H, Letteboer Tom G W, Hoogerbrugge Nicoline, Harryvan Jan, Kampman Ellen, Morreau Hans, Vasen Hans F A, van Wezel Tom
Abstract excerpt
BACKGROUND: Colorectal adenomatous polyposis is associated with a high risk of colorectal cancer (CRC) and is frequently caused by germline mutations in APC or MUTYH. However, in about 20-30% of patients no underlying gene defect can be identified. In this study, we tested if recently identified CRC risk variants play a role in patients with >10 adenomas. METHODS: We analysed a total of 16 SNPs with a reported...
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