Article
Aberrantly expressed HIF-1α enhances HCC stem cell-like traits via Wnt/β-catenin signaling activation after insufficient radiofrequency ablation.
Journal of cancer research and therapeutics - 1 Dec 2023
Zhang Ning, Chen Ruoxue, Cao Xin, Wang Lu
Abstract excerpt
BACKGROUND: Radiofrequency ablation has become a favorable treatment modality for small hepatocellular carcinoma (HCC) recently; however, insufficient radiofrequency ablation (RFA) was shown to lead to enhanced invasiveness and metastasis of HCC in our previous study, while the underlying molecular mechanism has not been understood. MATERIALS AND METHODS: In order to explore the influence of the hypoxic...
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