Article
Systemic dysregulation of TDP-43 binding microRNAs in amyotrophic lateral sclerosis.
Acta neuropathologica communications - 30 Jul 2013
Freischmidt Axel, Müller Kathrin, Ludolph Albert C, Weishaupt Jochen H
Abstract excerpt
BACKGROUND: A pathological hallmark of most amyotrophic lateral sclerosis (ALS) cases are intracellular aggregates of the protein TDP-43. The pathophysiological relevance of TDP-43 is underlined by familial ALS cases caused by TDP-43 mutations. TDP-43 is involved in processing of both coding RNAs and microRNAs, which are key epigenetic regulators of transcriptome plasticity and suspected to contribute to...
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