Article
Serum microRNAs in sporadic amyotrophic lateral sclerosis.
Neurobiology of aging - 1 Sept 2015
Freischmidt Axel, Müller Kathrin, Zondler Lisa, Weydt Patrick, Mayer Benjamin, von Arnim Christine A F, Hübers Annemarie, Dorst Johannes, Otto Markus, Holzmann Karlheinz, Ludolph Albert C, Danzer Karin M, Weishaupt Jochen H
Abstract excerpt
MicroRNAs (miRNAs) are post-transcriptional regulators of gene expression and specific mircoRNA "fingerprints" are thought to contribute to and/or reflect certain disease conditions. Recently, we identified surprisingly homogeneous signatures of circulating miRNAs in the serum of familial amyotrophic lateral sclerosis (ALS) patients, which were already present in presymptomatic carriers of ALS gene mutations....
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