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Article

4G/5G promoter polymorphism in the plasminogen-activator-inhibitor-1 gene in children with systemic meningococcaemia.

European journal of pediatrics - 1 Aug 2005

Geishofer Gotho, Binder Alexander, Müller Martin, Zöhrer Bettina, Resch Bernhard, Müller Wilhelm, Faber Jörg, Finn Adam, Endler Georg, Mannhalter Christine, Zenz Werner

Abstract excerpt

UNLABELLED: Meningococcal disease may present as sepsis, meningitis or a combination of both. Impaired fibrinolysis and massive elevation of the plasminogen activator inhibitor-1 (PAI-1) is a characteristic feature of meningococcal sepsis. Previously, an association between mortality and the functional 4G/5G promoter polymorphism of the PAI-1gene in a cohort of UK and Dutch children with meningococcal sepsis was...

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PMID: 15843979
DOI: 10.1007/s00431-005-1673-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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