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Article

Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.

Small GTPases - 1 Jan 2000

Hobbs G Aaron, Gunawardena Harsha P, Baker Rachael, Campbell Sharon L

Abstract excerpt

KRas has recently been shown to be activated by monoubiquitination (mUb). Similar to oncogenic mutations, mUb of Ras at position 147 activates Ras by causing a defect in GTPase activating protein (GAP) function. To characterize the mechanism by which mUb impairs GAP-mediated downregulation of Ras...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24030601
DOI: 10.4161/sgtp.26270
PMCID: PMC3976977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24030601-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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