Article
Site-specific monoubiquitination activates Ras by impeding GTPase-activating protein function.
Small GTPases - 1 Jan 2000
Hobbs G Aaron, Gunawardena Harsha P, Baker Rachael, Campbell Sharon L
Abstract excerpt
KRas has recently been shown to be activated by monoubiquitination (mUb). Similar to oncogenic mutations, mUb of Ras at position 147 activates Ras by causing a defect in GTPase activating protein (GAP) function. To characterize the mechanism by which mUb impairs GAP-mediated downregulation of Ras, we made various modifications at position 147 of Ras and examined the impact on Ras sensitivity to GAP function....
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