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Article

GNAS1 and PHD2 short-interfering RNA support bone regeneration in vitro and in an in vivo sheep model.

Clinical orthopaedics and related research - 1 Sept 2012

Ríos Carmen N, Skoracki Roman J, Mathur Anshu B

Abstract excerpt

BACKGROUND: Our ability to guide cells in biomaterials for in vivo bone repair is limited and requires novel strategies. Short-interfering RNA (siRNA) allows the regulation of multiple cellular pathways. Core binding factor alpha 1 (Cbfa1) and hypoxia-inducible factor 1 (HIF-1) pathways can be modulated to direct bone formation via siRNA against guanine nucleotide-binding protein alpha-stimulating activity...

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Identifiers

PMID: 22833384
DOI: 10.1007/s11999-012-2475-4
PMCID: PMC3830105

Genes

MSC

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