Article
Mutation and methylation analysis of the chromodomain-helicase-DNA binding 5 gene in ovarian cancer.
Neoplasia (New York, N.Y.) - 1 Nov 2008
Gorringe Kylie L, Choong David Yh, Williams Louise H, Ramakrishna Manasa, Sridhar Anita, Qiu Wen, Bearfoot Jennifer L, Campbell Ian G
Abstract excerpt
Chromodomain, helicase, DNA binding 5 (CHD5) is a member of a subclass of the chromatin remodeling Swi/Snf proteins and has recently been proposed as a tumor suppressor in a diverse range of human cancers. We analyzed all 41 coding exons of CHD5 for somatic mutations in 123 primary ovarian cancers as well as 60 primary breast cancers using high-resolution melt analysis. We also examined methylation of the CHD5...
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