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GATA4 and GATA5 are Potential Tumor Suppressors and Biomarkers in Colorectal Cancer

15 Jun 2009

Abstract excerpt

PURPOSE: The transcription factors GATA4 and GATA5 are involved in gastrointestinal development and are inactivated by promoter hypermethylation in colorectal cancer. Here, we evaluated GATA4/5 promoter methylation as potential biomarkers for noninvasive colorectal cancer detection, and investigated the role of GATA4/5 in colorectal cancer. EXPERIMENTAL DESIGN: Promoter methylation of GATA4/5 was analyzed in...

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PMID: 19509152
DOI: 10.1158/1078-0432.ccr-09-0055

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