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A study of the association between chronic superficial keratitis and polymorphisms in the upstream regulatory regions of DLA-DRB1, DLA-DQB1 and DLA-DQA1.

Veterinary immunology and immunopathology - 15 Dec 2013

Barrientos Laura S, Zapata Gustavo, Crespi Julian A, Posik Diego M, Díaz Silvina, It Veronica, Peral-García Pilar, Giovambattista Guillermo

Abstract excerpt

Canine chronic superficial keratitis (CSK) is an inflammatory corneal disease that primarily occurs in German shepherd dogs (GSDs). Several studies support the hypothesis that CSK is an immune-mediated disease. To investigate the genetic factors associated with CSK development, the upstream regulatory regions (URRs) of the DLA-DRB, -DQA and -DQB genes were genotyped in 60 dogs, including 32 CSK animals. LD...

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PMID: 24238945
DOI: 10.1016/j.vetimm.2013.10.009

Genes

CSK

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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