Article
Multiple regulatory variants located in cell type-specific enhancers within the PKP2 locus form major risk and protective haplotypes for canine atopic dermatitis in German shepherd dogs.
BMC genetics - 29 Jun 2016
Tengvall Katarina, Kozyrev Sergey, Kierczak Marcin, Bergvall Kerstin, Farias Fabiana H G, Ardesjö-Lundgren Brita, Olsson Mia, Murén Eva, Hagman Ragnvi, Leeb Tosso, Pielberg Gerli, Hedhammar Åke, Andersson Göran, Lindblad-Toh Kerstin
Abstract excerpt
BACKGROUND: Canine atopic dermatitis (CAD) is a chronic inflammatory skin disease triggered by allergic reactions involving IgE antibodies directed towards environmental allergens. We previously identified a ~1.5 Mb locus on canine chromosome 27 associated with CAD in German shepherd dogs (GSDs). Fine-mapping indicated association closest to the PKP2 gene encoding plakophilin 2. RESULTS: Additional genotyping and...
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