Article
The black sheep of the family- whole-exome sequencing in family of lithium response discordant bipolar monozygotic twins.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 May 2020
Jacobs Asaf, Hagin Michal, Shugol Miraz, Shomron Noam, Pillar Nir, Fañanás Lourdes, Serretti Alessandro, Vieta Eduard, Popovic Dina
Abstract excerpt
Twin studies are among the most promising strategies for studying heritable disorders, including bipolar disorder (BD). The aim of the present study was to identify distinguishing genes between monozygotic (MZ) twins with different BD phenotype and compare them to their non-affected siblings. Whole-exome sequencing (WES) can identify rare and structural variants that could detect the polygenetic burden of complex...
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