Article
De novo variation in bipolar disorder.
Molecular psychiatry - 1 Aug 2021
Goes Fernando S, Pirooznia Mehdi, Tehan Martin, Zandi Peter P, McGrath John, Wolyniec Paula, Nestadt Gerald, Pulver Ann E
Abstract excerpt
Bipolar disorder (BD) is a common, highly heritable disorder that affects 1-2% of the world's population. To date, most genetic studies of BD have focused on common gene variation, and while robustly associated loci have been identified, a substantial proportion of the heritability remains missing and could be partially attributable to rare variation. In this study, we apply a de novo paradigm in BD to identify...
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