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Article

An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.

PloS one - 23 Nov 2010

Cao Fang, Chen Yong, Cierpicki Tomasz, Liu Yifan, Basrur Venkatesha, Lei Ming, Dou Yali

Abstract excerpt

Histone H3 lysine 4 (K4) methylation is a prevalent mark associated with transcription activation and is mainly catalyzed by the MLL/SET1 family histone methyltransferases. A common feature of the mammalian MLL/SET1 complexes is the presence of three core components (RbBP5, Ash2L and WDR5) and a catalytic subunit containing a SET domain. Unlike most other histone lysine methyltransferases, all four proteins are...

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PMID: 21124902
DOI: 10.1371/journal.pone.0014102
PMCID: PMC2990719

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SET

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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An Ash2L/RbBP5 heterodimer stimulates the MLL1 methyltransferase activity through coordinated substrate interactions with the MLL1 SET domain.PMID 21124902Read ↗

Targeting human SET1/MLL family of proteinsSemantic proximity Read ↗

Somatic cancer mutations in the MLL1 histone methyltransferase modulate its enzymatic activity and dependence on the WDR5/RBBP5/ASH2L complex.Semantic proximity Read ↗

Targeted Disruption of the Interaction between WD-40 Repeat Protein 5 (WDR5) and Mixed Lineage Leukemia (MLL)/SET1 Family Proteins Specifically Inhibits MLL1 and SETd1A Methyltransferase Complexes.Semantic proximity Read ↗

Automethylation activities within the mixed lineage leukemia-1 (MLL1) core complex reveal evidence supporting a "two-active site" model for multiple histone H3 lysine 4 methylation.Semantic proximity Read ↗

Catalytic and functional roles of conserved amino acids in the SET domain of the S. cerevisiae lysine methyltransferase Set1.Semantic proximity Read ↗

Coactivator as a target gene specificity determinant for histone H3 lysine 4 methyltransferases.Semantic proximity Read ↗

ASH2L Deficiency in Smooth Muscle Drives Pulmonary Vascular RemodelingSemantic proximity Read ↗

Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding.Semantic proximity Read ↗

SET8 recognizes the sequence RHRK20VLRDN within the N terminus of histone H4 and mono-methylates lysine 20.Semantic proximity Read ↗

Crystal Structure of Cardiac-specific Histone Methyltransferase SmyD1 Reveals Unusual Active Site ArchitectureSemantic proximity Read ↗

Sequence specificity analysis of the SETD2 protein lysine methyltransferase and discovery of a SETD2 super-substrate.Semantic proximity Read ↗

Association of the histone methyltransferase Set2 with RNA polymerase II plays a role in transcription elongation.Semantic proximity Read ↗

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