Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Drug screening in a zebrafish model of Duchenne muscular dystrophy.

Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 2011

Kawahara Genri, Karpf Jeremy A, Myers Jennifer A, Alexander Matthew S, Guyon Jeffrey R, Kunkel Louis M

Abstract excerpt

Two known zebrafish dystrophin mutants, sapje and sapje-like (sap(c/100)), represent excellent small-animal models of human muscular dystrophy. Using these dystrophin-null zebrafish, we have screened the Prestwick chemical library for small molecules that modulate the muscle phenotype in these fish. With a quick and easy birefringence assay, we have identified seven small molecules that influence muscle pathology...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Oligonucleotides, Antisense
Share to Pharmaceutical Preparations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Animals, Genetically Modified

Share to Drug Evaluation, Preclinical

Share to Dystrophin

Share to Muscular Dystrophy, Duchenne

Share to Small Molecule Libraries

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 21402949
DOI: 10.1073/pnas.1102116108
PMCID: PMC3069215

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Drug screening in a zebrafish model of Duchenne muscular dystrophy.PMID 21402949Read ↗

Fluoxetine prevents dystrophic changes in a zebrafish model of Duchenne muscular dystrophy.Semantic proximity Read ↗

Epigenetic small molecule screening identifies a new HDACi compound for ameliorating Duchenne muscular dystrophySemantic proximity Read ↗

A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophySemantic proximity Read ↗

Recent advances using zebrafish animal models for muscle disease drug discoverySemantic proximity Read ↗

Muscular dystrophy modeling in zebrafish.Semantic proximity Read ↗

Dystrophin-deficient zebrafish feature aspects of the Duchenne muscular dystrophy pathology.Semantic proximity Read ↗

Muscle dysfunction and structural defects of dystrophin-null sapje mutant zebrafish larvae are rescued by ataluren treatment.Semantic proximity Read ↗

Dystrophic muscle improvement in zebrafish via increased heme oxygenase signalingSemantic proximity Read ↗

Standardization of zebrafish drug testing parameters for muscle diseasesSemantic proximity Read ↗

Duchenne muscular dystrophy animal models for high-throughput drug discovery and precision medicine.Semantic proximity Read ↗

The Accordion Zebrafish tq206 Mutant in the Assessment of a Novel Pharmaceutical Approach to Brody Myopathy.Semantic proximity Read ↗

[Therapeutic drug screening with zebrafish models].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.