Article
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.
Human molecular genetics - 1 Apr 2014
Goris An, van Setten Jessica, Diekstra Frank, Ripke Stephan, Patsopoulos Nikolaos A, Sawcer Stephen J, van Es Michael, Andersen Peter M, Melki Judith, Meininger Vincent, Hardiman Orla, Landers John E, Brown Robert H, Shatunov Aleksey, Leigh Nigel, Al-Chalabi Ammar, Shaw Christopher E, Traynor Bryan J, Chiò Adriano, Restagno Gabriella, Mora Gabriele, Ophoff Roel A, Oksenberg Jorge R, Van Damme Philip, Compston Alastair, Robberecht Wim, Dubois Bénédicte, van den Berg Leonard H, De Jager Philip L, Veldink Jan H, de Bakker Paul I W
Abstract excerpt
Genome-wide association studies have been successful in identifying common variants that influence the susceptibility to complex diseases. From these studies, it has emerged that there is substantial overlap in susceptibility loci between diseases. In line with those findings, we hypothesized that shared genetic pathways may exist between multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). While both...
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