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Article

Serum concentrations of risperidone and aripiprazole in subgroups encoding CYP2D6 intermediate metabolizer phenotype.

Therapeutic drug monitoring - 1 Feb 2014

Hendset Magnhild, Molden Espen, Knape Magnus, Hermann Monica

Abstract excerpt

BACKGROUND: Cytochrome P450 2D6 intermediate metabolizer phenotype (CYP2D6 IM) comprises various genotype subgroups. The aim of this study was to evaluate serum concentrations of the CYP2D6 substrates risperidone and aripiprazole in psychiatric patients with various CYP2D6 genotypes encoding IM phenotype. METHODS: The study was based on therapeutic drug monitoring data from CYP2D6-genotyped patients (mainly of...

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Aged, 80 and over
Administration, Oral
Antipsychotic Agents
Cytochrome P-450 CYP2D6
Dose-Response Relationship, Drug

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 24232129
DOI: 10.1097/FTD.0000000000000018

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