Article
UNC79 and UNC80, putative auxiliary subunits of the NARROW ABDOMEN ion channel, are indispensable for robust circadian locomotor rhythms in Drosophila.
PloS one - 1 Jan 2013
Lear Bridget C, Darrah Eric J, Aldrich Benjamin T, Gebre Senetibeb, Scott Robert L, Nash Howard A, Allada Ravi
Abstract excerpt
In the fruit fly Drosophila melanogaster, a network of circadian pacemaker neurons drives daily rhythms in rest and activity. The ion channel NARROW ABDOMEN (NA), orthologous to the mammalian sodium leak channel NALCN, functions downstream of the molecular circadian clock in pacemaker neurons to promote behavioral rhythmicity. To better understand the function and regulation of the NA channel, we have...
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