Article
Superinfection with drug-resistant HIV is rare and does not contribute substantially to therapy failure in a large European cohort.
BMC infectious diseases - 12 Nov 2013
Bartha István, Assel Matthias, Sloot Peter M A, Zazzi Maurizio, Torti Carlo, Schülter Eugen, De Luca Andrea, Sönnerborg Anders, Abecasis Ana B, Van Laethem Kristel, Rosi Andrea, Svärd Jenny, Paredes Roger, van de Vijver David A M C, Vandamme Anne-Mieke, Müller Viktor
Abstract excerpt
BACKGROUND: Superinfection with drug resistant HIV strains could potentially contribute to compromised therapy in patients initially infected with drug-sensitive virus and receiving antiretroviral therapy. To investigate the importance of this potential route to drug resistance, we developed a bioinformatics pipeline to detect superinfection from routinely collected genotyping data, and assessed whether...
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