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Article

Association of human aging with a functional variant of klotho.

Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2002

Arking Dan E, Krebsova Alice, Macek Milan, Macek Milan, Arking Albert, Mian I Saira, Fried Linda, Hamosh Ada, Dey Srabani, McIntosh Iain, Dietz Harry C

Abstract excerpt

Mice deficient in Klotho gene expression exhibit a syndrome resembling premature human aging. To determine whether variation in the human KLOTHO locus contributes to survival, we applied two newly characterized polymorphic microsatellite markers flanking the gene in a population-based association study. In a cohort chosen for its homogeneity, Bohemian Czechs, we demonstrated significant differences in selected...

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Identifiers

PMID: 11792841
DOI: 10.1073/pnas.022484299
PMCID: PMC117395

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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