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Article

A guide for the design of evolve and resequencing studies.

Molecular biology and evolution - 1 Feb 2014

Kofler Robert, Schlötterer Christian

Abstract excerpt

Standing genetic variation provides a rich reservoir of potentially useful mutations facilitating the adaptation to novel environments. Experimental evolution studies have demonstrated that rapid and strong phenotypic responses to selection can also be obtained in the laboratory. When combined with the next-generation sequencing technology, these experiments promise to identify the individual loci contributing to...

Topics

Adaptation, Physiological
Animals
Computational Biology
Computer Simulation
Drosophila melanogaster
Female
Genes, Insect
Genetic Loci
Genetic Variation
Genome, Insect
Linkage Disequilibrium

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Phenotype

Reproducibility of Results

Selection, Genetic

Sequence Analysis, DNA

Source

Open in PubMed Open full text

Identifiers

PMID: 24214537
DOI: 10.1093/molbev/mst221
PMCID: PMC3907048

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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