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Article

Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute myeloid leukemia cells correlate with altered KIT expression.

Experimental hematology - 1 Feb 2014

Herrmann Markus D, Lennerz Jochen K, Bullinger Lars, Bartholomae Stephan, Holzmann Karlheinz, Westhoff Mike-Andrew, Corbacioglu Selim, Debatin Klaus-Michael

Abstract excerpt

KIT inhibition with dasatinib represents a promising approach to targeted therapy in t(8;21) acute myeloid leukemia (AML) and clinical trials are currently evaluating its clinical relevance. However, data on continuous long-term dasatinib exposure of AML cells are limited and the potential effects on KIT inhibition and dasatinib sensitivity are unexplored. Treatment-related resistance ultimately limits clinical...

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Source

Identifiers

PMID: 24211243
DOI: 10.1016/j.exphem.2013.10.006

Genes

KIT
STAT3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transitory dasatinib-resistant states in KIT(mut) t(8;21) acute myeloid leukemia cells correlate with altered KIT expression.PMID 24211243Read ↗

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