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Dasatinib inhibits proliferation and induces apoptosis in the KASUMI-1 cell line bearing the t(8;21)(q22;q22) and the N822K c-kit mutation.

Leukemia research - 1 Feb 2013

Mpakou Vassiliki E, Kontsioti Frieda, Papageorgiou Sotiris, Spathis Aris, Kottaridi Christine, Girkas Kostas, Karakitsos Petros, Dimitriadis George, Dervenoulas Ioannis, Pappa Vasiliki

Abstract excerpt

Activating mutations of the c-kit gene are frequently found in CBF (core binding factor) leukemias. We evaluated the effect of tyrosine kinase inhibitor dasatinib in leukemic cell lines bearing or not c-kit mutations. Our data demonstrate that in the AML Kasumi-1 cell line, bearing the N822K c-kit mutation, dasatinib is a potent suppressor of c-kit and Src kinase activity and inhibits the phosphorylation of their...

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PMID: 23149070
DOI: 10.1016/j.leukres.2012.10.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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