Article
Primary over-expression of AβPP in muscle does not lead to the development of inclusion body myositis in a new lineage of the MCK-AβPP transgenic mouse.
International journal of experimental pathology - 1 Dec 2013
Luo Yue-Bei, Johnsen Russell D, Griffiths Lisa, Needham Merrilee, Fabian Victoria A, Fletcher Sue, Wilton Steve D, Mastaglia Frank L
Abstract excerpt
The aim of this study is to determine whether primary over-expression of AβPP in skeletal muscle results in the development of features of inclusion body myositis (IBM) in a new lineage of the MCK-AβPP transgenic mouse. Quantitative histological, immunohistochemical and western blotting studies were performed on muscles from 3 to 18 month old transgenic and wild-type C57BL6/SJL mice. Electron microscopy was also...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.