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Article

Inclusion body myositis-like phenotype induced by transgenic overexpression of beta APP in skeletal muscle.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2002

Sugarman Michael C, Yamasaki Tritia R, Oddo Salvatore, Echegoyen Julio C, Murphy M Paul, Golde Todd E, Jannatipour Mehrdad, Leissring Malcolm A, LaFerla Frank M

Abstract excerpt

Inclusion body myositis (IBM), the most common age-related muscle disease in the elderly population, is an incurable disorder leading to severe disability. Sporadic IBM has an unknown etiology, although affected muscle fibers are characterized by many of the pathobiochemical alterations traditionally associated with neurodegenerative brain disorders such as Alzheimer's disease. Accumulation of the amyloid-beta...

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Share to Amyloid beta-Protein Precursor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11972038
DOI: 10.1073/pnas.082545599
PMCID: PMC122949

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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