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Article

Inhibition of IGF-1R prevents ionizing radiation-induced primary endothelial cell senescence.

PloS one - 1 Jan 2013

Panganiban Ronald Allan M, Day Regina M

Abstract excerpt

Accelerated senescence is a primary response to cellular stresses including DNA damaging agents (e.g., ionizing radiation) and is widely believed to be caused by continuous proliferative signaling in the presence of cell cycle arrest. Studies of signal transduction pathways leading to accelerated senescence have revealed that inhibition of mammalian target of rapamycin (mTOR) by rapamycin rescues cells from...

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Identifiers

PMID: 24205274
DOI: 10.1371/journal.pone.0078589
PMCID: PMC3813482

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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