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Article

Inhibition of Sirtuin 6 Induces Neuroblastoma Differentiation

20 Jan 2018

Abstract excerpt

Background/Aim: Sirtuins (SIRTs) play crucial roles in various signaling pathways that modulate differentiation and proliferation. We sought to elucidate the role of SIRTs in differentiation and proliferation of human neuroblastoma (NB). Materials and Methods: NB cells were treated with nicotinamide (NAM), a non-specific SIRT inhibitor, SIRT-targeted short hairpin RNAs, and retinoic acid to assess cell growth and...

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PMID: 29374686
DOI: 10.21873/anticanres.12268

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