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Article

Using genetic prediction from known complex disease Loci to guide the design of next-generation sequencing experiments.

PloS one - 1 Jan 2013

Jostins Luke, Levine Adam P, Barrett Jeffrey C

Abstract excerpt

A central focus of complex disease genetics after genome-wide association studies (GWAS) is to identify low frequency and rare risk variants, which may account for an important fraction of disease heritability unexplained by GWAS. A profusion of studies using next-generation sequencing are seeking such risk alleles. We describe how already-known complex trait loci (largely from GWAS) can be used to guide the...

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Identifiers

PMID: 24204614
DOI: 10.1371/journal.pone.0076328
PMCID: PMC3799779

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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