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Article

Dual Roles of PARP-1 Promote Cancer Growth and Progression

19 Sept 2012

Abstract excerpt

UNLABELLED: PARP-1 is an abundant nuclear enzyme that modifies substrates by poly(ADP-ribose)-ylation. PARP-1 has well-described functions in DNA damage repair and also functions as a context-specific regulator of transcription factors. With multiple models, data show that PARP-1 elicits protumorigenic effects in androgen receptor (AR)-positive prostate cancer cells, in both the presence and absence of genotoxic...

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PMID: 22993403
DOI: 10.1158/2159-8290.cd-12-0120

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