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Article

Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma.

The Journal of clinical investigation - 1 Dec 2013

Marsh Durban Victoria, Deuker Marian M, Bosenberg Marcus W, Phillips Wayne, McMahon Martin

Abstract excerpt

Malignant melanoma is frequently driven by mutational activation of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) accompanied by silencing of the phosphatase and tensin homology (PTEN) tumor suppressor. Despite the implied importance of PI3K signaling in PTENNull melanomas, mutational activation of the gene encoding the catalytic subunit of PI3Kα (PIK3CA), is rarely detected. Since PTEN has both PI3-lipid...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24200692
DOI: 10.1172/JCI69619
PMCID: PMC3859393

Genes

PTEN
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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