Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma.

The Journal of clinical investigation - 1 Dec 2013

Marsh Durban Victoria, Deuker Marian M, Bosenberg Marcus W, Phillips Wayne, McMahon Martin

Abstract excerpt

Malignant melanoma is frequently driven by mutational activation of v-raf murine sarcoma viral oncogene homolog B1 (BRAF) accompanied by silencing of the phosphatase and tensin homology (PTEN) tumor suppressor. Despite the implied importance of PI3K signaling in PTENNull melanomas, mutational act...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Class I Phosphatidylinositol 3-Kinases
Share to Melanoma, Experimental
Share to Phosphatidylinositol 3-Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Phosphoinositide-3 Kinase Inhibitors

Share to Protein Processing, Post-Translational

Share to Proto-Oncogene Proteins c-akt

Share to PTEN Phosphohydrolase

Share to Specific Pathogen-Free Organisms

Source

Open in PubMed Open full text

Identifiers

PMID: 24200692
DOI: 10.1172/JCI69619
PMCID: PMC3859393

Genes

PTEN
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-24200692-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma.PMID 24200692Read ↗

Braf(V600E) cooperates with Pten loss to induce metastatic melanoma.Semantic proximity Read ↗

PI3′-Kinase Inhibition Forestalls the Onset of MEK1/2 Inhibitor Resistance in <i>BRAF</i> -Mutated MelanomaSemantic proximity Read ↗

AKT2 Loss Impairs BRAF-Mutant Melanoma MetastasisSemantic proximity Read ↗

PTEN signaling pathways in melanoma.Semantic proximity Read ↗

Concurrent loss of the PTEN and RB1 tumor suppressors attenuates RAF dependence in melanomas harboring (V600E)BRAF.Semantic proximity Read ↗

BRAF inhibitor resistance mediated by the AKT pathway in an oncogenic BRAF mouse melanoma modelSemantic proximity Read ↗

PERK mediates resistance to BRAF inhibition in melanoma with impaired PTENSemantic proximity Read ↗

Revisiting the Clinical and Biologic Relevance of Partial PTEN Loss in Melanoma.Semantic proximity Read ↗

Targeting BRAFV600E in an inducible murine model of melanoma.Semantic proximity Read ↗

AXL/AKT axis mediated-resistance to BRAF inhibitor depends on PTEN status in melanoma.Semantic proximity Read ↗

Genetic silencing of AKT induces melanoma cell deathSemantic proximity Read ↗

A novel AKT1 mutant amplifies an adaptive melanoma response to BRAF inhibition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.